Reseach Highlights

My current primary research interests and expertise are developing novel nanoparticle carriers for gene/drug delivery, designing microfluidics-based formulation methods to rationally control nanoparticle properties, engineering new strategies and devices to facilitate sample preparation in electron microscopy for single particle reconstruction, and exploring alternative strategies to facilitate protein crystallization success.

Gene & Drug Delivery

Microfluidic Assembly of Nanoparticles

Microfluidic Assembly of Nanoparticles

Continuous and segmented microfluidic strategies are being used as uniqe methods to drive the self-assembly of novel pendant polymer (e.g., hyaluronic acid-adamantane & cationic β-cyclodextrin) and polyrotaxane systems as therapeutics to facilitate gene and drug delivery. Currently targeted diseases are wide-ranging, including a variety of cancers and Niemann-Pick Type C disease. My strategies include developing materials poised to avoid many problematic factors in the field (e.g. efficiency, biocompatibility, and biodegradability). Further, microfluidic-mediated control of nanoparticle properties such as size, polydispersity, and complexation/decomplexation ability has been published and is presently being explored more rigorously.

Protein Structure Determination

Templated Protein Crystallization

Templated Protein Crystallization

Due to the general lack of rational methods to guide protein crystallization, schemes are in development for facilitating protein crystallization and allowing structural information to be obtained for previously "uncrystallizable" proteins. Affinity ligands provide the scaffold for templated crystallization in bulk solution (left) and at monolayer interfaces (right).